ParkinsonCanadaV1, Main, Exploration, bibRecord, 002101

Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning

Identifieur interne : 002101 ( Main/Exploration ); précédent : 002100; suivant : 002102

Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning

Auteurs : Stuart W. S. Macdonald [Canada, Suède] ; Simon Cervenka [Suède] ; Lars Farde [Suède] ; Lars Nyberg [Suède] ; Lars B Ckman [Suède]

Source :

Neuropsychologia [ 0028-3932 ] ; 2009.

RBID : Pascal:09-0481526

Descripteurs français

Pascal (Inist)
- Récepteur dopaminergique D2, Comparaison intraindividuelle, Reconnaissance mnémonique, Fonction exécutive, Tomoscintigraphie, Dopamine, Cortex extrastrié, Mémoire épisodique, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- D2 Dopamine receptor, Dopamine, Emission tomography, Episodic memory, Executive function, Extrastriate cortex, Human, Intraindividual comparison, Recognition memory.

Abstract

Intraindividual variability (IIV) reflects lawful but transient within-person changes in performance. Increased IIV in cognition shares systematic associations with numerous conditions characterized by alterations in dopamine (DA) neuromodulation (e.g., old age, ADHD, schizophrenia, and Parkinson's disease). In a group of normal middle-aged adults, we examined links between PET-derived measures of D2 receptor binding in striatum, orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and hippocampus (HC) and IIV for tasks assessing recognition memory and executive functioning. An index of IIV, the intraindividual standard deviation (ISD), was computed across successful response latency trials for each cognitive outcome. Lower D2 binding in OC, ACC, and HC, but not striatum, was associated with increasing ISDs for the memory and executive measures. Consistent with neurocomputational models, the present findings suggest a role for extrastriatal DA neurotransmission in modulating variability in cognitive functioning.

Affiliations:

Canada, Suède

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Intraindividual variability (IIV) reflects lawful but transient within-person changes in performance. Increased IIV in cognition shares systematic associations with numerous conditions characterized by alterations in dopamine (DA) neuromodulation (e.g., old age, ADHD, schizophrenia, and Parkinson's disease). In a group of normal middle-aged adults, we examined links between PET-derived measures of D2 receptor binding in striatum, orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and hippocampus (HC) and IIV for tasks assessing recognition memory and executive functioning. An index of IIV, the intraindividual standard deviation (ISD), was computed across successful response latency trials for each cognitive outcome. Lower D2 binding in OC, ACC, and HC, but not striatum, was associated with increasing ISDs for the memory and executive measures. Consistent with neurocomputational models, the present findings suggest a role for extrastriatal DA neurotransmission in modulating variability in cognitive functioning.</div>
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Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning

Extrastriatal dopamine D2 receptor binding modulates intraindividual variability in episodic recognition and executive functioning

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri